RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
mir-199a-2
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
Dual-luciferase reporter assay; qRT-PCR; etc.
Target
Hif-1a
Pathway
NA
PubMed ID
Title
Peroxisome proliferator-activated receptor-a-mediated transcription of miR-199a2 attenuates endothelin-1 expression via hypoxia-inducible factor-1a
Year
2014
Function
"Placenta growth factor(PlGF) treatment of endothelial cells resulted in reduced levels of miR-199a2, which targeted the 3'-UTR of HIF-1a mRNA and concomitantly led to augmented ET-1 expression. Fenofibrate, a PPARa agonist, increased the expression of miR-199a2, which was responsible for reduced expression of HIF-1a and ET-1. In vivo studies of fenofibrate-fed Berkeley sickle mice resulted in increased levels of miR-199a2 and reduced levels of ET-1 in lung tissues. Fenofibrate-induced miR-199a2 expression can ameliorate PH by reduction of ET-1 levels."